it's contraindicated in Females who will be or may well turn out to be pregnant. If the patient turns into Expecting though getting the drug, she needs to be apprised on the likely hazard to your fetus. Nephrosis or even the nephrotic period of nephritis. Hypersensitivity to the drug. extreme hepatic dysfunction.
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Females needs to be observed for signs of virilization (deepening of the voice, hirsutism, acne and clitoromegaly). To prevent irreversible improve, drug therapy have to be discontinued when gentle virilism is initial detected. this kind of virilization is normal following androgenic anabolic steroid use at large doses. Some virilizing modifications in Gals are irreversible even right after prompt discontinuance of therapy and so are not prevented by concomitant use of estrogens.
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